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学科主题: 生命有机化学
题名: A selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress
其他题名: A selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress
作者: Michael Boyce1 ; Kevin F. Bryant ; Céline Jousse ; Long K(龙凯) ; Heather P.Harding ; Donalyn Scheuner ; Ma DW(马大为) ; Donald M. Coen ; David Ron ; Yuan JY(袁钧瑛)
通讯作者: Kevin F. Bryant ; Céline Jousse ; 龙凯
刊名: Science
发表日期: 2005
卷: 307, 期:5711, 页:935-939
收录类别: SCI
部门归属: 上海有机所; Harvard Univ
英文摘要: Most protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for small molecules that protect cells from endoplasmic reticulum (ER) stress, we,identified salubrinal, a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha). Salubrinal also blocks eIF2alpha dephosphorylation mediated by a herpes simplex virus protein and inhibits viral replication. These results suggest that selective chemical inhibitors of eIF2a dephosphorylation may be useful in diseases involving ER stress or viral infection. More broadly, salubrinal demonstrates the feasibility of selective pharmacological targeting of cellular dephosphorylation events.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000226985100057
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15499
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Michael Boyce1,Kevin F. Bryant,Céline Jousse,et al. A selective inhibitor-of eIF2 alpha dephosphorylation protects cells from ER stress[J]. Science,2005,307(5711):935-939.
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