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学科主题: 生命有机化学
题名: Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases
其他题名: 抑制哺乳动物组氨去酰化酶的免疫抑制剂-环四肽FR235222的全合成
作者: Xie WQ(谢卫青) ; Zou B(邹斌) ; Pei DQ(裴端卿) ; Ma DW(马大为)
通讯作者: 马大为
刊名: Org. Lett.
发表日期: 2005
卷: 7, 期:13, 页:2775-2777
收录类别: SCI
部门归属: 上海有机所; 中科院广州生殖研究所
英文摘要: yThe total synthesis of FR235222, a potent immunosuppressant with in vivo activities, has been achieved. The key steps include assembling its (2S,9R)-2-amino-9-hydroxy-8-oxodecanoic acid residue via an olefin cross-metathesis of a methyl (R)-lactate-derived homoallyl ketone with protected allyl amino acid and constructing its trans-(2R,4S)-4-methylproline unit from protected (R)-pyroglutamic acid in seven steps.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000229952100065
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15489
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Xie WQ,Zou B,Pei DQ,et al. Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases[J]. Org. Lett.,2005,7(13):2775-2777.
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