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学科主题: 生命有机化学
题名: Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative
其他题名: salubrinal的结构-活性关系研究及其生物素化的活性衍生物的合成
作者: Long K(龙凯) ; Lin H(林何) ; Michael Boyce ; Ma DW(马大为)
通讯作者: 马大为
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2005
卷: 15, 期:17, 页:3849-3852
收录类别: SCI
部门归属: 上海有机所; 哈佛大学
英文摘要: The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification. (c) 2005 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000231186000007
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15485
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Long K,Lin H,Michael Boyce,et al. Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative[J]. Bioorg. Med. Chem. Lett.,2005,15(17):3849-3852.
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