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学科主题: 生命有机化学
题名: An efficient and tunable route to AG7088, a rhinovirus protease inhibitor
其他题名: An efficient and tunable route to AG7088, a rhinovirus protease inhibitor
作者: Ma DW(马大为) ; Xie WQ(谢卫青) ; Zou B(邹斌) ; LEI QIONG ; Pei DQ(裴端卿)
通讯作者: 马大为
刊名: Tetrahedron Lett.
发表日期: 2004
卷: 45, 期:43, 页:8103-8105
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring opening afford the acid 2a, which is coupled with the amine 3 and 5-methylisoxazole-3-carboxylate acid 1, respectively, to deliver AG7088. (C) 2004 Elsevier Ltd. All rights reserved
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000224447600031
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15475
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ma DW,Xie WQ,Zou B,et al. An efficient and tunable route to AG7088, a rhinovirus protease inhibitor[J]. Tetrahedron Lett.,2004,45(43):8103-8105.
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