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学科主题: 生命有机化学
题名: Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
其他题名: Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors
作者: Ma DW(马大为) ; Wu WG(吴问根) ; Yang GX(杨国新) ; LI JINGYA ; Li J(李佳) ; Ye QZ(叶其壮)
通讯作者: 马大为 ; 叶其壮
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2004
卷: 14, 期:1, 页:47-50
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室; 中国科学院上海药物所
英文摘要: The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups. (C) 2003 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000187862000007
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15473
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ma DW,Wu WG,Yang GX,et al. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors[J]. Bioorg. Med. Chem. Lett.,2004,14(1):47-50.
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