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Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal
Alternative TitleCo-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal
Wang P(王平); Ma DW(马大为); J. Keski-Oja; Pei DQ(裴端卿)
2004
Source PublicationJ. Biol. Chem.
ISSN0021-9258
Volume279Issue:10Pages:9331-9336
AbstractMembers of the membrane-type matrix metalloproteinases (MT-MMPs) have been implicated in a wide range of physiological and pathological processes from normal development to tumor growth. Tethered on plasma membrane, these enzymes are potentially regulated by the trafficking machinery of the cells. Here we demonstrate that both MT1-MMP and MT3-MMP are internalized, transported to the trans-Golgi network through early endosomes, and recycled back to cell surface in 60 min in a manner distinct from the one employed by transferrin receptor. Interestingly, co-expressed MT1-MMP and MT3-MMP are localized and routed in the same vesicles throughout the trafficking process. We further demonstrated that the carboxyl-terminal sequence DKV582 of MT1-MMP is required for its recycling, thus defining a novel recycling motif. These results suggest that MT-MMPs may coordinate their proteolytic activities through the cellular trafficking machinery.
Subject Area生命有机化学
Department美国明尼苏达大学; 中国科学院上海有机化学研究所生命有机化学实验室
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Indexed BySCI
Language英语
WOS IDWOS:000189265900096
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/15469
Collection生命有机化学国家重点实验室
Corresponding AuthorPei DQ(裴端卿)
Recommended Citation
GB/T 7714
Wang P,Ma DW,J. Keski-Oja,et al. Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal[J]. J. Biol. Chem.,2004,279(10):9331-9336.
APA 王平,马大为,J. Keski-Oja,&裴端卿.(2004).Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal.J. Biol. Chem.,279(10),9331-9336.
MLA 王平,et al."Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal".J. Biol. Chem. 279.10(2004):9331-9336.
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