中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal
其他题名: Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal
作者: Wang P(王平) ; Ma DW(马大为) ; J. Keski-Oja ; Pei DQ(裴端卿)
通讯作者: 裴端卿
刊名: J. Biol. Chem.
发表日期: 2004-01-01
卷: 279, 期:10, 页:9331-9336
收录类别: SCI
部门归属: 美国明尼苏达大学; 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: Members of the membrane-type matrix metalloproteinases (MT-MMPs) have been implicated in a wide range of physiological and pathological processes from normal development to tumor growth. Tethered on plasma membrane, these enzymes are potentially regulated by the trafficking machinery of the cells. Here we demonstrate that both MT1-MMP and MT3-MMP are internalized, transported to the trans-Golgi network through early endosomes, and recycled back to cell surface in 60 min in a manner distinct from the one employed by transferrin receptor. Interestingly, co-expressed MT1-MMP and MT3-MMP are localized and routed in the same vesicles throughout the trafficking process. We further demonstrated that the carboxyl-terminal sequence DKV582 of MT1-MMP is required for its recycling, thus defining a novel recycling motif. These results suggest that MT-MMPs may coordinate their proteolytic activities through the cellular trafficking machinery.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000189265900096
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15469
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2004267.pdf(639KB)----开放获取--View Download

Recommended Citation:
Wang P,Ma DW,J. Keski-Oja,et al. Co-recycling of MT1-MMP and MT3-MMP through the trans-Golgi network - Identification of DKV582 as a recycling signal[J]. J. Biol. Chem.,2004,279(10):9331-9336.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王平]'s Articles
[马大为]'s Articles
[J. Keski-Oja]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王平]‘s Articles
[马大为]‘s Articles
[J. Keski-Oja]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2004267.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace