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学科主题: 生命有机化学
题名: Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
其他题名: Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
作者: Xia YF(夏贻丰) ; 叶BUQING ; Wang, JG ; He, XJ ; Lin XF(林宪峰) ; Yao XS(姚新生) ; Ma DW(马大为) ; Slungaard, A ; Hebbel, RP ; Key, NS ; Geng JG(耿建国)
通讯作者: 夏贻丰 ; 叶BUQING ; 耿建国
刊名: J. Immunol.
发表日期: 2004
卷: 173, 期:6, 页:4207-4217
收录类别: SCI
部门归属: 中国科学院细胞所; 沈阳药科大学; 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: NF-kappaB is a central transcriptional factor and a pleiotropic regulator of many genes involved in immunological responses. During the screening of a plant extract library of traditional Chinese herbal medicines, we found that NF-kappaB activity was potently inhibited by andrographolide (Andro), an abundant component of the plant Andrographis that has been commonly used as a folk remedy for alleviation of inflammatory disorders in Asia for millennia. Mechanistically, it formed a covalent adduct with reduced cysteine (62) of p50, thus blocking the binding of NF-kappaB oligonucleotide to nuclear proteins. Andro suppressed the activation of NF-kappaB in stimulated endothelial cells, which reduced the expression of cell adhesion molecule E-selectin and prevented E-selectin-mediated leukocyte adhesion under flow. It also abrogated the cytokine- and endotoxin-induced peritoneal deposition of neutrophils, attenuated septic shock, and prevented allergic lung inflammation in vivo. Notably, it had no suppressive effect on IkappaBalpha degradation, p50 and p65 nuclear translocation, or cell growth rates. Our results thus reveal a unique pharmacological mechanism of Andro's protective anti-inflammatory actions.
语种: 英语
WOS记录号: WOS:000223878000073
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15453
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Xia YF,叶BUQING,Wang, JG,et al. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50[J]. J. Immunol.,2004,173(6):4207-4217.
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