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Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
其他题名Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
Xia YF(夏贻丰); 叶BUQING; Wang, JG; He, XJ; Lin XF(林宪峰); Yao XS(姚新生); Ma DW(马大为); Slungaard, A; Hebbel, RP; Key, NS; Geng JG(耿建国)
2004
发表期刊J. Immunol.
ISSN0022-1767
卷号173期号:6页码:4207-4217
摘要NF-kappaB is a central transcriptional factor and a pleiotropic regulator of many genes involved in immunological responses. During the screening of a plant extract library of traditional Chinese herbal medicines, we found that NF-kappaB activity was potently inhibited by andrographolide (Andro), an abundant component of the plant Andrographis that has been commonly used as a folk remedy for alleviation of inflammatory disorders in Asia for millennia. Mechanistically, it formed a covalent adduct with reduced cysteine (62) of p50, thus blocking the binding of NF-kappaB oligonucleotide to nuclear proteins. Andro suppressed the activation of NF-kappaB in stimulated endothelial cells, which reduced the expression of cell adhesion molecule E-selectin and prevented E-selectin-mediated leukocyte adhesion under flow. It also abrogated the cytokine- and endotoxin-induced peritoneal deposition of neutrophils, attenuated septic shock, and prevented allergic lung inflammation in vivo. Notably, it had no suppressive effect on IkappaBalpha degradation, p50 and p65 nuclear translocation, or cell growth rates. Our results thus reveal a unique pharmacological mechanism of Andro's protective anti-inflammatory actions.
学科领域生命有机化学
部门归属中国科学院细胞所; 沈阳药科大学; 中国科学院上海有机化学研究所生命有机化学实验室
收录类别SCI
语种英语
WOS记录号WOS:000223878000073
引用统计
被引频次:222[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/15453
专题生命有机化学国家重点实验室
通讯作者Xia YF(夏贻丰); 叶BUQING; Geng JG(耿建国)
推荐引用方式
GB/T 7714
Xia YF,叶BUQING,Wang, JG,et al. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50[J]. J. Immunol.,2004,173(6):4207-4217.
APA 夏贻丰.,叶BUQING.,Wang, JG.,He, XJ.,林宪峰.,...&耿建国.(2004).Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.J. Immunol.,173(6),4207-4217.
MLA 夏贻丰,et al."Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50".J. Immunol. 173.6(2004):4207-4217.
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