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Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer
Alternative Title(-)-alkaloid 223A 合其六位异构体的不对称全合成
Pu XT(蒲晓涛); Ma DW(马大为)
2003
Source PublicationJ. Org. Chem.
ISSN0022-3263
Volume68Issue:11Pages:4400-4405
AbstractThe enantiopure γ-amino alcohols 7 and 18 are prepared by using the diastereoselective michael addition of lithium N-benzyl ( R )-α-methylbenzylamide to α,β-unsaturated esters as a key step. The michael addition of 7 or 18 to an alkynone 8 followed by an intramolecular cyclization afford the cyclic enzmine 10 or 20. which are subjected to the diastereoselective hydrogenation, and the subsequent transformations provide 6-epi-alkaloid 223A and alkaloid 223A, respectively.
Subject Area生命有机化学
Department中国科学院上海有机化学研究所生命有机国家开放实验室
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Indexed BySCI
Language英语
WOS IDWOS:000183066100033
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/15449
Collection生命有机化学国家重点实验室
Corresponding AuthorMa DW(马大为)
Recommended Citation
GB/T 7714
Pu XT,Ma DW. Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer[J]. J. Org. Chem.,2003,68(11):4400-4405.
APA 蒲晓涛,&马大为.(2003).Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer.J. Org. Chem.,68(11),4400-4405.
MLA 蒲晓涛,et al."Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer".J. Org. Chem. 68.11(2003):4400-4405.
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