| Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer | |
| Alternative Title | (-)-alkaloid 223A 合其六位异构体的不对称全合成 |
| Pu XT(蒲晓涛); Ma DW(马大为) | |
| 2003 | |
| Source Publication | J. Org. Chem.
 |
| ISSN | 0022-3263 |
| Volume | 68Issue:11Pages:4400-4405 |
| Abstract | The enantiopure γ-amino alcohols 7 and 18 are prepared by using the diastereoselective michael addition of lithium N-benzyl ( R )-α-methylbenzylamide to α,β-unsaturated esters as a key step. The michael addition of 7 or 18 to an alkynone 8 followed by an intramolecular cyclization afford the cyclic enzmine 10 or 20. which are subjected to the diastereoselective hydrogenation, and the subsequent transformations provide 6-epi-alkaloid 223A and alkaloid 223A, respectively. |
| Subject Area | 生命有机化学 |
| Department | 中国科学院上海有机化学研究所生命有机国家开放实验室 |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000183066100033 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sioc.ac.cn/handle/331003/15449 |
| Collection | 生命有机化学国家重点实验室 |
| Corresponding Author | Ma DW(马大为) |
| Recommended Citation GB/T 7714 | Pu XT,Ma DW. Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer[J]. J. Org. Chem.,2003,68(11):4400-4405. |
| APA | 蒲晓涛,&马大为.(2003).Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer.J. Org. Chem.,68(11),4400-4405. |
| MLA | 蒲晓涛,et al."Asymmetric total synthesis of (-)-Alkaloid 223A and its 6-epimer".J. Org. Chem. 68.11(2003):4400-4405. |
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| File Name/Size | DocType | Version | Access | License | ||
| 2003306.pdf（141KB） | 开放获取 | -- | Application Full Text | |||
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