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Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C lsozymes
Alternative Title7-取代苯并八元内酰胺的合成及其对蛋白激酶C异构的选择性
Ma DW(马大为); Tang GZ(唐国志); AP. Kozikowshi
2002-01-01
Source PublicationOrg. Lett.
ISSN1523-7060
Volume4Issue:14Pages:2377-2380
AbstractCondensation of L-valine benzyl ester toluenesulfonic acid salt with a substituted cyclohexadione followed by aromatization with the assistance of NBS provides and N_aryl L-valine benzyl ester. This intermediate is converted into 7-subsituted benzolactam-V8s using an asymmetric strecker reaction as the key step. The target molecules show a different pattern of isozyme selectivity relative to the 8-substituted benzolactam-V8s.
Subject Area生命有机化学
Department中国科学院上海有机化学研究所生命有机化学实验室
URL查看原文
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/15419
Collection生命有机化学国家重点实验室
Corresponding AuthorMa DW(马大为)
Recommended Citation
GB/T 7714
Ma DW,Tang GZ,AP. Kozikowshi. Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C lsozymes[J]. Org. Lett.,2002,4(14):2377-2380.
APA 马大为,唐国志,&AP. Kozikowshi.(2002).Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C lsozymes.Org. Lett.,4(14),2377-2380.
MLA 马大为,et al."Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C lsozymes".Org. Lett. 4.14(2002):2377-2380.
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