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学科主题: 生命有机化学
题名: A short synthesis of the HIV-protease inhibitor nelfinavir via a diastereoselective addition of ammonia to the α,β-unsaturated sulfoxide derived from ?-glyceraldehyde acetonide
其他题名: 通过氨气与甘油醛衍生物的不饱和亚砜的非对映选择性加成对于HIV--蛋白水解酶抑制剂neifinavir的较短合成
作者: Ma DW(马大为) ; Zou B(邹斌) ; Zhu W(竺伟) ; Xu HD(徐华栋)
通讯作者: 马大为
刊名: Tetrahedron Lett.
发表日期: 2002-01-01
卷: 43, 期:47, 页:8511-8513
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室
英文摘要: Diastereoselective michael addition of ammonia to sulfoxide 3a derved from ?-glyceraldehyde acetonide provides amine 4a. Which is converted into nelfinavir using BF^3.Et^2O/NaI reduction and subsequent coupling reactions as key steps.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15415
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ma DW,Zou B,Zhu W,et al. A short synthesis of the HIV-protease inhibitor nelfinavir via a diastereoselective addition of ammonia to the α,β-unsaturated sulfoxide derived from ?-glyceraldehyde acetonide[J]. Tetrahedron Lett.,2002,43(47):8511-8513.
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