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学科主题: 生命有机化学
题名: Recent advances in the discovery of protein kinase C modulators based on the structures of natural protein kinase C activators
其他题名: 基于天然的蛋白激酶C活性剂结构的蛋白酶C调节剂的研究现状
作者: Ma DW(马大为)
通讯作者: 马大为
刊名: Curr. Med. Chem.
发表日期: 2001-01-01
卷: 8, 期:2, 页:191-202
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家重点实验室
英文摘要: The natural products teleocidins, phorbol ester, asplysiatoxin, ingenol ester, and bryostatins are all potent protein kinase C(PKC) activator. The fact that they act at the same site of PKC implied that these structurally diverse molecules might contain the common structural elements. Several pharmacophores for these compounds have been proposed based on the molecular modeling studied and experimental results. In order to prove these hypotheses various simplified analogues of these compounds are designed, synthesized, and evaluated as new PKC activators. Some of the simplified analogues demonstrated much high potency to activate PKC, which not only gives some insights how these PKC activators bind with PKC, but also provides the new leads to develop the therapeutic tools to treat the diseases related by PKC.
语种: 英语
WOS记录号: WOS:000166723200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15403
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ma DW. Recent advances in the discovery of protein kinase C modulators based on the structures of natural protein kinase C activators[J]. Curr. Med. Chem.,2001,8(2):191-202.
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