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学科主题: 生命有机化学
题名: Synthesis of 7,8-Disubstituted benzolactam-V8 and its binding to protein kinase C
其他题名: 7,8-二取代苯并八元内酰胺的合成及其对于蛋白激酶C的效应
作者: Ma DW(马大为) ; Zhang T(张涛) ; Wang GQ(王国强) ; Alan P. Kozikowski ; Nancy E. Lewin ; Peter M. Blumberg
通讯作者: 马大为 ; Alan P. Kozikowski
刊名: BIOORG. MED. CHEM. LETT.
发表日期: 2001
卷: 11, 期:2, 页:99-101
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室; Drug Discovery Laboratory, Institute for Cognitive & Computational Science, Georgetown University Medical Center
英文摘要: 7- Methoxy-8-decynyl-benzolactam-V8- 4 is synthesized using a catalytic asymmetric alkylation reaction as a key step. This compound shows potent activity to three PKC isozymes tested (Ki=45.6,91.1, and 121,.3 nM to PKCα,δ, and ε, respectively), indicating that introduction of a suitable suitable substituent at the 7-position of 8-decynyl-benzolactam-V8 only slightly reduces the PKC binding affinity.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000166648100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15389
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ma DW,Zhang T,Wang GQ,et al. Synthesis of 7,8-Disubstituted benzolactam-V8 and its binding to protein kinase C[J]. BIOORG. MED. CHEM. LETT.,2001,11(2):99-101.
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