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学科主题: 生命有机化学
题名: Synthesis and biological activity of 1-amioindan-1,3-dicar-boxylic acid, a benzo-analogue of (1S,3R)-ACPD
其他题名: 苯并(1S,3R)-ACPD的合成和活性
作者: Ding K(丁克) ; Zhang XR(张欣荣) ; Ma DW(马大为) ; Wang BM(王保民)
通讯作者: 马大为
刊名: Chin. J. Chem.
发表日期: 2001-01-01
卷: 19, 期:12, 页:1232-1238
收录类别: SCI
部门归属: 复旦大学; 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: Amino acids 1 and 2 were designed and synthesized as the conformationally constrained analogues of (1S,3R)-or (1S,3S)-ACPDs, and the selective agonists of mGluRs. The synthesis started from (R)-phenylglycine using Seebach's stereocenter self-regeneration method and intramolecular acylaion as key steps. No activity was found when 1 and 2 were tested as either mGluR agonist or antagonist.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15387
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ding K,Zhang XR,Ma DW,et al. Synthesis and biological activity of 1-amioindan-1,3-dicar-boxylic acid, a benzo-analogue of (1S,3R)-ACPD[J]. Chin. J. Chem.,2001,19(12):1232-1238.
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