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学科主题: 天然产物有机化学
题名: Synthesis and protein kinase C binding-activity of benzolactam-V7
其他题名: 苯并七元内酰胺的合成及与PKC的结合活性
作者: Ma DW(马大为) ; Wang GQ(王国强) ; Wang SM(王绍蒙) ; Alan P. Kozikowski ; Nancy E. Lwwin ; Peter M. Blumberg
通讯作者: 马大为 ; Alan P. Kozikowski
刊名: Bioorg. Med. Chem. Lett.
发表日期: 1999-01-01
卷: 9, 页:1371-1374
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学国家重点实验室; Drug Disocovery Laboratory, Institute for Cognitive & Computational Sciences, Georgetown University Medical Center
英文摘要: Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesizedand evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/15349
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ma DW,Wang GQ,Wang SM,et al. Synthesis and protein kinase C binding-activity of benzolactam-V7[J]. Bioorg. Med. Chem. Lett.,1999,9:1371-1374.
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