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Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations
其他题名简便的一步法合成氟取代二氢吡喃衍生物及其进一步化学转化
Wang PY(王鹏远); Song LP(宋力平); Yi H(易海); Zhang M(张敏); Zhu SZ(朱仕正); Deng HM(邓红梅); Shao M(邵敏)
2010
发表期刊Tetrahedron Lett.
ISSN0040-4039
卷号51期号:30页码:3975-3977
摘要One-pot four-component reactions of aromatic aldehyde, Meldrum's acid, ethyl-4,4,4-trifluoro-1,3-dioxobutanoate, and ammonium acetate afford ethyl 2-hydroxy-6-oxo-4-aryl-2-(trifluoromethyl)piperidine-3-carboxylate in good yields. The one-pot four-component process consists of an initial Michael addition, and a subsequent intramolecular cyclization. The effect of solvents on the reaction efficiency and yield is briefly investigated. The structure of product is further confirmed by XRD analysis. Meanwhile, the further transformation of hemi-aminal moiety to the corresponding dehydrated product is also achieved under the mild reaction conditions. The possible mechanism for the formation of product is presented. (C) 2010 Elsevier Ltd. All rights reserved.
学科领域有机氟化学
部门归属上海大学; 中国科学院上海有机化学研究所
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收录类别SCI
语种英语
WOS记录号WOS:000279817400029
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/14488
专题中科院有机氟化学重点实验室
通讯作者Song LP(宋力平); Zhu SZ(朱仕正)
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GB/T 7714
Wang PY,Song LP,Yi H,et al. Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations[J]. Tetrahedron Lett.,2010,51(30):3975-3977.
APA 王鹏远.,宋力平.,易海.,张敏.,朱仕正.,...&邵敏.(2010).Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations.Tetrahedron Lett.,51(30),3975-3977.
MLA 王鹏远,et al."Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations".Tetrahedron Lett. 51.30(2010):3975-3977.
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