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学科主题: 有机氟化学
题名: Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations
其他题名: 简便的一步法合成氟取代二氢吡喃衍生物及其进一步化学转化
作者: Wang PY(王鹏远) ; Song LP(宋力平) ; Yi H(易海) ; Zhang M(张敏) ; Zhu SZ(朱仕正) ; Deng HM(邓红梅) ; Shao M(邵敏)
通讯作者: 宋力平 ; 朱仕正
刊名: Tetrahedron Lett.
发表日期: 2010
卷: 51, 期:30, 页:3975-3977
收录类别: SCI
部门归属: 上海大学; 中国科学院上海有机化学研究所
英文摘要: One-pot four-component reactions of aromatic aldehyde, Meldrum's acid, ethyl-4,4,4-trifluoro-1,3-dioxobutanoate, and ammonium acetate afford ethyl 2-hydroxy-6-oxo-4-aryl-2-(trifluoromethyl)piperidine-3-carboxylate in good yields. The one-pot four-component process consists of an initial Michael addition, and a subsequent intramolecular cyclization. The effect of solvents on the reaction efficiency and yield is briefly investigated. The structure of product is further confirmed by XRD analysis. Meanwhile, the further transformation of hemi-aminal moiety to the corresponding dehydrated product is also achieved under the mild reaction conditions. The possible mechanism for the formation of product is presented. (C) 2010 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000279817400029
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/14488
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Wang PY,Song LP,Yi H,et al. Convenient one-pot synthesis of fluorinated DHPs derivatives and their further transformations[J]. Tetrahedron Lett.,2010,51(30):3975-3977.
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