| Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives |
| 其他题名 | 3－脱氧－2－酮糖酸及其衍生物的合成发展
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| Li LS(李连生); Wu YL(吴毓林)
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| 2003
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| 发表期刊 | Curr. Org. Chem.
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| ISSN | 1385-2728
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| 卷号 | 7期号:5页码:447-475 |
| 摘要 | Higher 3-deoxy-2-ulosonic acids are a family of widely distributed natural high carbon carbohydrates, of which 3-deoxy-D-arabino-hept-2-ulosonic acid(DAH), 3-deoxy-D-manno-oct-2-ulosonic acid (KDO),2), 3-Deoy-D-glycero-D-galacton-non-2-ulosonic acid (KDN) and 5-acetamido-3,5-dideoxy-D-glecero-D-glecero-D-galacto-non-2-ulosonic acid (N-acetylneuraminic acid) are the most common members. These sugars have been demonstrated to play vital roles in a series of biochemical and biological processes. The family of ulosonic acids has provided potential therapeutic leadds in developing inhibitors of corresponding enzymes. Zanamivir (5) is a transition state analogue of 2,3-didehydro-2-deoxy-N_acetylneuraminic acid (Neu5Ac2en), which exhibits high inhibitory activity to influenza neuraminidase (NA) and has been appoved for the treatment of influenza. Therefore, the syntheses of these ulosonic acids themselves and their analogs have attacted considerable intereest inrecent years, and become a current research topic. Herewith the recent progresses in the synthesi of these ulosonic acids and their derivatives are reviewed. |
| 学科领域 | 生命有机化学
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| 部门归属 | 中国科学院上海有机化学研究所生命有机国家重点实验室
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| 收录类别 | SCI
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| 语种 | 英语
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| WOS记录号 | WOS:000181184000003
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.sioc.ac.cn/handle/331003/14068
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| 专题 | 生命有机化学国家重点实验室
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| 通讯作者 | Wu YL(吴毓林) |
推荐引用方式
GB/T 7714 |
Li LS,Wu YL. Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives[J]. Curr. Org. Chem.,2003,7(5):447-475.
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| APA |
李连生,&吴毓林.(2003).Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives.Curr. Org. Chem.,7(5),447-475.
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| MLA |
李连生,et al."Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives".Curr. Org. Chem. 7.5(2003):447-475.
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