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学科主题: 生命有机化学
题名: Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives
其他题名: 3-脱氧-2-酮糖酸及其衍生物的合成发展
作者: Li LS(李连生) ; Wu YL(吴毓林)
通讯作者: 吴毓林
刊名: Curr. Org. Chem.
发表日期: 2003
卷: 7, 期:5, 页:447-475
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家重点实验室
英文摘要: Higher 3-deoxy-2-ulosonic acids are a family of widely distributed natural high carbon carbohydrates, of which 3-deoxy-D-arabino-hept-2-ulosonic acid(DAH), 3-deoxy-D-manno-oct-2-ulosonic acid (KDO),2), 3-Deoy-D-glycero-D-galacton-non-2-ulosonic acid (KDN) and 5-acetamido-3,5-dideoxy-D-glecero-D-glecero-D-galacto-non-2-ulosonic acid (N-acetylneuraminic acid) are the most common members. These sugars have been demonstrated to play vital roles in a series of biochemical and biological processes. The family of ulosonic acids has provided potential therapeutic leadds in developing inhibitors of corresponding enzymes. Zanamivir (5) is a transition state analogue of 2,3-didehydro-2-deoxy-N_acetylneuraminic acid (Neu5Ac2en), which exhibits high inhibitory activity to influenza neuraminidase (NA) and has been appoved for the treatment of influenza. Therefore, the syntheses of these ulosonic acids themselves and their analogs have attacted considerable intereest inrecent years, and become a current research topic. Herewith the recent progresses in the synthesi of these ulosonic acids and their derivatives are reviewed.
语种: 英语
WOS记录号: WOS:000181184000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/14068
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Li LS,Wu YL. Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives[J]. Curr. Org. Chem.,2003,7(5):447-475.
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