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Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives
Alternative Title3-脱氧-2-酮糖酸及其衍生物的合成发展
Li LS(李连生); Wu YL(吴毓林)
2003
Source PublicationCurr. Org. Chem.
ISSN1385-2728
Volume7Issue:5Pages:447-475
AbstractHigher 3-deoxy-2-ulosonic acids are a family of widely distributed natural high carbon carbohydrates, of which 3-deoxy-D-arabino-hept-2-ulosonic acid(DAH), 3-deoxy-D-manno-oct-2-ulosonic acid (KDO),2), 3-Deoy-D-glycero-D-galacton-non-2-ulosonic acid (KDN) and 5-acetamido-3,5-dideoxy-D-glecero-D-glecero-D-galacto-non-2-ulosonic acid (N-acetylneuraminic acid) are the most common members. These sugars have been demonstrated to play vital roles in a series of biochemical and biological processes. The family of ulosonic acids has provided potential therapeutic leadds in developing inhibitors of corresponding enzymes. Zanamivir (5) is a transition state analogue of 2,3-didehydro-2-deoxy-N_acetylneuraminic acid (Neu5Ac2en), which exhibits high inhibitory activity to influenza neuraminidase (NA) and has been appoved for the treatment of influenza. Therefore, the syntheses of these ulosonic acids themselves and their analogs have attacted considerable intereest inrecent years, and become a current research topic. Herewith the recent progresses in the synthesi of these ulosonic acids and their derivatives are reviewed.
Subject Area生命有机化学
Department中国科学院上海有机化学研究所生命有机国家重点实验室
Indexed BySCI
Language英语
WOS IDWOS:000181184000003
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/14068
Collection生命有机化学国家重点实验室
Corresponding AuthorWu YL(吴毓林)
Recommended Citation
GB/T 7714
Li LS,Wu YL. Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives[J]. Curr. Org. Chem.,2003,7(5):447-475.
APA 李连生,&吴毓林.(2003).Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives.Curr. Org. Chem.,7(5),447-475.
MLA 李连生,et al."Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives".Curr. Org. Chem. 7.5(2003):447-475.
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