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Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives
其他题名3-脱氧-2-酮糖酸及其衍生物的合成发展
Li LS(李连生); Wu YL(吴毓林)
2003
发表期刊Curr. Org. Chem.
ISSN1385-2728
卷号7期号:5页码:447-475
摘要Higher 3-deoxy-2-ulosonic acids are a family of widely distributed natural high carbon carbohydrates, of which 3-deoxy-D-arabino-hept-2-ulosonic acid(DAH), 3-deoxy-D-manno-oct-2-ulosonic acid (KDO),2), 3-Deoy-D-glycero-D-galacton-non-2-ulosonic acid (KDN) and 5-acetamido-3,5-dideoxy-D-glecero-D-glecero-D-galacto-non-2-ulosonic acid (N-acetylneuraminic acid) are the most common members. These sugars have been demonstrated to play vital roles in a series of biochemical and biological processes. The family of ulosonic acids has provided potential therapeutic leadds in developing inhibitors of corresponding enzymes. Zanamivir (5) is a transition state analogue of 2,3-didehydro-2-deoxy-N_acetylneuraminic acid (Neu5Ac2en), which exhibits high inhibitory activity to influenza neuraminidase (NA) and has been appoved for the treatment of influenza. Therefore, the syntheses of these ulosonic acids themselves and their analogs have attacted considerable intereest inrecent years, and become a current research topic. Herewith the recent progresses in the synthesi of these ulosonic acids and their derivatives are reviewed.
学科领域生命有机化学
部门归属中国科学院上海有机化学研究所生命有机国家重点实验室
收录类别SCI
语种英语
WOS记录号WOS:000181184000003
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/14068
专题生命有机化学国家重点实验室
通讯作者Wu YL(吴毓林)
推荐引用方式
GB/T 7714
Li LS,Wu YL. Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives[J]. Curr. Org. Chem.,2003,7(5):447-475.
APA 李连生,&吴毓林.(2003).Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives.Curr. Org. Chem.,7(5),447-475.
MLA 李连生,et al."Recent progress in syntheses of Higher 3-Deoxy-2-ulosonic acids and their derivatives".Curr. Org. Chem. 7.5(2003):447-475.
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