中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Study on the mechanism of action of artemether against Schistosomes: The identification of cysteine adducts of both carbon-centred free radicals derived from artemether
其他题名: 青蒿甲醚虐机制研究: 青蒿甲醚的两种碳自由基和半胱氨酸加成物的鉴定
作者: Wu WM(吴文敏) ; Chen YL(陈燕莉) ; Xiao SH(肖树华) ; Zhai ZL(翟自立) ; Wu YL(吴毓林)
通讯作者: 吴毓林
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2003
卷: 13, 期:10, 页:1645-1647
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家重点实验室; 中国预防医学科学院寄生虫研究所
英文摘要: Reaction of the antimalarial and anti-schistosome drug artemether (1) and catalytic amount of ferrous ion in the presence of excess cysteine gave two adducts of cystieine and previous postulated primary and secondary carbon-centred free radicals besides their other rearrangement products. This piece of further evidence for the presence of carbon-centred radicals, especially the secondary carbon-centred free radical for the first time by the isolation of its coupling adduct, will be help to understand the mechanism of action of artemether and other qinghaosu derivatives against parasties.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000182913600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/14060
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2003014.pdf(134KB)----开放获取--View Download

Recommended Citation:
Wu WM,Chen YL,Xiao SH,et al. Study on the mechanism of action of artemether against Schistosomes: The identification of cysteine adducts of both carbon-centred free radicals derived from artemether[J]. Bioorg. Med. Chem. Lett.,2003,13(10):1645-1647.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[吴文敏]'s Articles
[陈燕莉]'s Articles
[肖树华]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[吴文敏]‘s Articles
[陈燕莉]‘s Articles
[肖树华]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2003014.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace