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学科主题: 生命有机化学
题名: Mimicry of annonaceous acetogenins: Enantioselective synthesis of a (4R)-hydroxy analogue having potent antiumor activity
其他题名: 对映选择性合成具有抗肿瘤活性的(4R)-羟基蕃荔枝内酯类似物
作者: Jiang S(蒋晟) ; Liu ZH(刘忠海) ; Shen G(沈刚) ; Ceng BB(曾步兵) ; Chen XG(陈晓光) ; Wu YL(吴毓林) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: J. Org. Chem.
发表日期: 2002-01-01
卷: 67, 期:10, 页:3404-3408
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室; 中国医学科学院药物所
英文摘要: The (4R)-hydroxylated analogues of annonaceous acetogenin mimicking compound 2 were designed and synthesized structurally on the basis of the naturally occurring annonaceous acetogenin bullatacin, which was discovered as a typical member of the novel family of polyketides with potent cytotoxicity, antitumoral. And other biological activities. The preliminary screenings show that the IC^50 values of 2 were 1.6×10~3 and 8×10~2 μg/mL agains HT-29 and HCT-8, respectively. A remarkable enhancement effect was observed by the activity comparison of 1c and its (4R)-hydroxylated analogue 2.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/14046
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Jiang S,Liu ZH,Shen G,et al. Mimicry of annonaceous acetogenins: Enantioselective synthesis of a (4R)-hydroxy analogue having potent antiumor activity[J]. J. Org. Chem.,2002,67(10):3404-3408.
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