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学科主题: 生命有机化学
题名: Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies
其他题名: 单克隆抗体催化的萘普生乙酯对映体选择性水解
作者: Shi ZD(史震旦) ; Yang BH(杨炳辉) ; Zhao JJ(赵晶晶) ; Wu YL(吴毓林) ; Ji YY(季永镛) ; Ye M(叶敏)
通讯作者: 杨炳辉 ; 吴毓林
刊名: Bioorg. Med. Chem.
发表日期: 2002
卷: 10, 期:7, 页:2171-2175
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机化学实验室; 上海细胞所
英文摘要: This report described that a hapten of racemic phosphonate 3 designed as the mimic of the transition state of hydrolysis of naproxen ethyl ester was successfully synthesized from easily available 2-zacetyl-6-methoxy-naphthalene 5. Then BALB/C mice were immunized and one of the monoclonal catalytic antibodies, N116-27, which enantioselectively accelerated the hydrolysis of the R-(-)-naproxen ethyl ester was give. The Michaelis-Menton parameter for the catalyzed reaction was K^M=6.67 mM and K^cat/K^uncat=5.8×10~4. This enantioselective result was explained by the fact that the R-isomer of rac-hapten was more immunogenic than the S-isomer.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000175649900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/14038
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Shi ZD,Yang BH,Zhao JJ,et al. Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies[J]. Bioorg. Med. Chem.,2002,10(7):2171-2175.
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