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学科主题: 有机化学
题名: General and effcient syntheses of C^18-4,8-Sphingadienines via S^N2'-type homoallylic coupling reactions mediated by thioether-stabilized copper geagents.
其他题名: 基于硫醚稳定的铜试剂所谋介的高烯丙位S^N2'偶联反应的G8-4,8-Sphingadienines 的通用高效合成
作者: Wang XZ(王祥柱) ; Wu YL(吴毓林) ; Shende Jiang ; Gurdial Singh
通讯作者: 吴毓林
刊名: J. Org. Chem.
发表日期: 2000-01-01
卷: 65, 期:24, 页:8146-8151
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室; University of Sunderland
英文摘要: The stereoselective syntheses of C^184,8-sphingadienines 3 and 4 as analogues of sphingosine 1 are described. The key step in these synteses involved a novel S^2'-type homoallylic coupling reaction between the corresponding thioether-stabilized alylic copper reagents and the allylic mesylate 7. The thioether-stabilized allylic copper reagents were easily prepared and retained the configuration of their double bond during the coupling reactions, thus overcoming the problem of isomerization which was normally associated with the use of allylic organometallic reagents in such applications.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/13990
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Wang XZ,Wu YL,Shende Jiang,et al. General and effcient syntheses of C^18-4,8-Sphingadienines via S^N2'-type homoallylic coupling reactions mediated by thioether-stabilized copper geagents.[J]. J. Org. Chem.,2000,65(24):8146-8151.
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