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学科主题: 生命有机化学
题名: How Chinese scientists discovered qinghaosu (Artemisinn) and developed its derivatives? What arethe future perspectives?
其他题名: 中国科学家们是如何发现青蒿素并发展其衍生物的? 前景如何?
作者: Li Y(李英) ; Wu YL(吴毓林)
刊名: Medecine Tropicale
发表日期: 1998-01-01
卷: 58, 期:suppl 3, 页:-12
部门归属: 上海药物所; 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: Since the middle of this century and especially since the 1960s nd 1970s, Chinese scientists have put considerable effort and resources into the search for new antimalarial compounds extracted from Chinese traditional herbs. Archaeological findings indicate that qinghao (Artemisia annua L.) has been used as a traditional remedy in China for over two thousand years. Its antimalarial principle was finally isolated in 1971 and namedartemisinin or qinghaosu(meaninthe principle of qinghao in Chinese). Its rapid action, low toxicity and powerful effect against falciparum malaria made it a favored subject for research. In 1976, the unique structure of the molecule, characterized by an endoperoxide and an alternative O-C-O-Csegment, was identified. The specific lactone reduction discoveredduring the determination of the structure opened the way for the synthesis of qinghaosu derivatives, and thereafter aseries of more active and more oil-or water-solubel derivatives was developed. Ssequent studies of the structure/activity relationship led to the discovery of dihydroartemisinin, artemether and artesunate. Now qinghaosu and these three derivatives are being used around the world as effective newantimalarial drugs in the fight against falciparun malaria, including multi-drug-resistantplasmodium falciparum. At the present time new qinghaosu analogues or derivatives are being developed and studies of their structure/activity relationships, their antimalarial mechanisms, their interaction with ferrous ions and the DNA damage associated with these processes are being actively pursued. In addition, recentstudies also indicate that some qinghaosu derivatives have other bioactivities, including antiparastic (against Schistosomajaponicum, Toxoplasma gondii and so on ) and anticancer activities. Reseach into qinghaosu and its derivatives has already produced and will no doubt continue to produce results of the utmost importance in the fight against malaria and other diseases.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/13958
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Li Y,Wu YL. How Chinese scientists discovered qinghaosu (Artemisinn) and developed its derivatives? What arethe future perspectives?[J]. Medecine Tropicale,1998,58(suppl 3):-12.
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