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How Chinese scientists discovered qinghaosu (Artemisinn) and developed its derivatives? What arethe future perspectives?
其他题名中国科学家们是如何发现青蒿素并发展其衍生物的? 前景如何?
Li Y(李英); Wu YL(吴毓林)
1998
发表期刊Medecine Tropicale
卷号58期号:suppl 3页码:-12
摘要Since the middle of this century and especially since the 1960s nd 1970s, Chinese scientists have put considerable effort and resources into the search for new antimalarial compounds extracted from Chinese traditional herbs. Archaeological findings indicate that qinghao (Artemisia annua L.) has been used as a traditional remedy in China for over two thousand years. Its antimalarial principle was finally isolated in 1971 and namedartemisinin or qinghaosu(meaninthe principle of qinghao in Chinese). Its rapid action, low toxicity and powerful effect against falciparum malaria made it a favored subject for research. In 1976, the unique structure of the molecule, characterized by an endoperoxide and an alternative O-C-O-Csegment, was identified. The specific lactone reduction discoveredduring the determination of the structure opened the way for the synthesis of qinghaosu derivatives, and thereafter aseries of more active and more oil-or water-solubel derivatives was developed. Ssequent studies of the structure/activity relationship led to the discovery of dihydroartemisinin, artemether and artesunate. Now qinghaosu and these three derivatives are being used around the world as effective newantimalarial drugs in the fight against falciparun malaria, including multi-drug-resistantplasmodium falciparum. At the present time new qinghaosu analogues or derivatives are being developed and studies of their structure/activity relationships, their antimalarial mechanisms, their interaction with ferrous ions and the DNA damage associated with these processes are being actively pursued. In addition, recentstudies also indicate that some qinghaosu derivatives have other bioactivities, including antiparastic (against Schistosomajaponicum, Toxoplasma gondii and so on ) and anticancer activities. Reseach into qinghaosu and its derivatives has already produced and will no doubt continue to produce results of the utmost importance in the fight against malaria and other diseases.
学科领域生命有机化学
部门归属上海药物所; 中国科学院上海有机化学研究所生命有机国家开放实验室
语种英语
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/13958
专题生命有机化学国家重点实验室
推荐引用方式
GB/T 7714
Li Y,Wu YL. How Chinese scientists discovered qinghaosu (Artemisinn) and developed its derivatives? What arethe future perspectives?[J]. Medecine Tropicale,1998,58(suppl 3):-12.
APA 李英,&吴毓林.(1998).How Chinese scientists discovered qinghaosu (Artemisinn) and developed its derivatives? What arethe future perspectives?.Medecine Tropicale,58(suppl 3),-12.
MLA 李英,et al."How Chinese scientists discovered qinghaosu (Artemisinn) and developed its derivatives? What arethe future perspectives?".Medecine Tropicale 58.suppl 3(1998):-12.
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