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学科主题: 天然产物有机化学
题名: The first total synthesis of 4-deoxyannomonatacin
其他题名: 4-脱氧-annomonatacin 的首次合成
作者: Yu Q(俞千) ; Wu YK(伍贻康) ; Ding H(丁辉) ; Wu YL(吴毓林)
通讯作者: 吴毓林
刊名: J. Chem. Soc.-Perkin Trans. 1
发表日期: 1999-01-01
页: 1183-1188
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: A convergen enantioselective total synthesis of 4-deoxyannomontacin, a newly isolated and characterized acetogenin compound which shows very high cytotoxicity, has been synthesized enantioselectively via 17 reaction steps with an overall yield of 15%. The four stereogenic centers near the ethereal link are derived from D-glucose and introduced using Sharpless asymmetric dihydroxylation. The chiral carbon in the butenolide moiety is taken from ethyl(S)-lactate whereas the hydroxy-group -configuration is obtained from salaenCo^Ⅲ-catalyzed hydrolytic kinetic resolution.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/13952
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Yu Q,Wu YK,Ding H,et al. The first total synthesis of 4-deoxyannomonatacin[J]. J. Chem. Soc.-Perkin Trans. 1,1999:1183-1188.
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