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Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.
其他题名亚铁离存在下青蒿素及其衍生物分子的作用-抗疟机制探讨
Wu YL(吴毓林); Chen HB(陈海宝); Jiang K(蒋昆); Li Y(李英); Shan F(山峰); Wang DY(王东业); Wang YF(王燕芳); Wu WM(吴文敏); Wu YK(伍贻康); Yao ZJ(姚祝军); Le ZY(乐征宇); Zhou CM(周澄明)
1999
发表期刊Pure Appl. Chem.
ISSN0033-4545
卷号71期号:6页码:1139-1142
摘要Qinghaosu(artemisinin) is the antimalarial principle of the Chinese traditional herb qinghao (Artemisia annua L.). Now qinghaosu and its derivatives have distinguished themselaves as a new generation of antimalarial drugs, especially in the treatment of multidrug-resistant cases. Qinghaosu has a unique carbon framework containing a special endoperoxy dridge, which is entirely different from that of all previous antimalarial agents and hence makes a novel antimalarial mechanism possible. Up to now there is still no clear picture about this mechanism at the molecular lever. However, the ferric/ferrous ions that are abundant in the red cell in which the parasite lives, is likely the most important co-factor for the antimalarial process of qinghaosu (scheme 1).
学科领域有机化学
部门归属中国科学院上海有机化学研究所生命有机国家开放实验室; 上海药物所
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收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/13946
专题生命有机化学国家重点实验室
通讯作者Wu YL(吴毓林)
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GB/T 7714
Wu YL,Chen HB,Jiang K,et al. Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.[J]. Pure Appl. Chem.,1999,71(6):1139-1142.
APA 吴毓林.,陈海宝.,蒋昆.,李英.,山峰.,...&周澄明.(1999).Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism..Pure Appl. Chem.,71(6),1139-1142.
MLA 吴毓林,et al."Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.".Pure Appl. Chem. 71.6(1999):1139-1142.
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