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学科主题: 有机化学
题名: Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.
其他题名: 亚铁离存在下青蒿素及其衍生物分子的作用-抗疟机制探讨
作者: Wu YL(吴毓林) ; Chen HB(陈海宝) ; Jiang K(蒋昆) ; Li Y(李英) ; Shan F(山峰) ; Wang DY(王东业) ; Wang YF(王燕芳) ; Wu WM(吴文敏) ; Wu YK(伍贻康) ; Yao ZJ(姚祝军) ; Le ZY(乐征宇) ; Zhou CM(周澄明)
通讯作者: 吴毓林
刊名: Pure Appl. Chem.
发表日期: 1999-01-01
卷: 71, 期:6, 页:1139-1142
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室; 上海药物所
英文摘要: Qinghaosu(artemisinin) is the antimalarial principle of the Chinese traditional herb qinghao (Artemisia annua L.). Now qinghaosu and its derivatives have distinguished themselaves as a new generation of antimalarial drugs, especially in the treatment of multidrug-resistant cases. Qinghaosu has a unique carbon framework containing a special endoperoxy dridge, which is entirely different from that of all previous antimalarial agents and hence makes a novel antimalarial mechanism possible. Up to now there is still no clear picture about this mechanism at the molecular lever. However, the ferric/ferrous ions that are abundant in the red cell in which the parasite lives, is likely the most important co-factor for the antimalarial process of qinghaosu (scheme 1).
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/13946
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Wu YL,Chen HB,Jiang K,et al. Interaction of biomolecules with qinghaosu (autemisinin) and its derivatives in the presence of ferrous ion-an exploration of antimalarial mechanism.[J]. Pure Appl. Chem.,1999,71(6):1139-1142.
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