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学科主题: 有机化学
题名: Radical-mediated construction of cyclopentane with concurrent formation of a well-defined quaternary center
其他题名: 用自由基反应关环制备带有确定手性季碳的环戊烷
作者: Zhu Q(朱强) ; Qiao LX(乔立新) ; Wu YK(伍贻康) ; Wu YL(吴毓林)
通讯作者: 吴毓林
刊名: J. Org. Chem.
发表日期: 1999-01-01
卷: 64, 期:7, 页:2428-2432
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室
英文摘要: Synthetic efforts toward the total synthesis of clavulactone dealing with enantioselective construction of the cyclopentane moiety are reported. With a novel radical-mediated cyclization as key step, the current approach allows for concurrent enantioselective construction of a quaternary chiral carbon at the cyclization step. The stereochemistries of the newly formed chiral centers are dictated by the configuration of the C-1 (cf. Numbering in 1). The high selectivity observed in this work is ascribed to the conformational advantage of the cyclic acetal, thich results in a much better defined transitions state than the previously used open-chain counterpart does.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000079690100047
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/13940
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Zhu Q,Qiao LX,Wu YK,et al. Radical-mediated construction of cyclopentane with concurrent formation of a well-defined quaternary center[J]. J. Org. Chem.,1999,64(7):2428-2432.
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