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学科主题: 天然产物有机化学
题名: Total synthesis of (10R)-and (10S)-corossolin: Determination of the stereochemistry at C-10of the natural corossoline and the differential toxicity toward cancer cells caused by the configuration at C-10
其他题名: (10R)及(10S)-Corossolin 的全合成及C-10构型的确定
作者: Yu Q(俞千) ; Yao ZJ(姚祝军) ; Chen XG(陈晓光) ; Wu YL(吴毓林)
通讯作者: 吴毓林
刊名: J. Org. Chem.
发表日期: 1999-01-01
卷: 64, 期:7, 页:2240-2445
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室; 北京药物所
英文摘要: (10R) and (10S)-corossolin have been synthesized by coupling of the alkyne intermediate 18 with epoxide 27 or 29, respectively. Comparison of the physical data of both synthetic corossolins with those reported for the natural one shows that the configuration at c-10 of the natural corossolin is highly likely to be R. The R isomer is found to be 18 times as active as the S isomer in the preliminary in vitro tests against the B16BL6 cell line.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/13938
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Yu Q,Yao ZJ,Chen XG,et al. Total synthesis of (10R)-and (10S)-corossolin: Determination of the stereochemistry at C-10of the natural corossoline and the differential toxicity toward cancer cells caused by the configuration at C-10[J]. J. Org. Chem.,1999,64(7):2240-2445.
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