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学科主题: 生命有机化学
题名: Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies
其他题名: 基于二苯基丁基哌啶结构的细胞自吞噬诱导剂: 合成与构效关系研究
作者: Chen G(陈刚) ; Xia HG(夏宏光) ; Cai Y(蔡俞) ; Ma DW(马大为) ; Yuan JY(袁钧瑛) ; Yuan CY(袁承业)
刊名: MedChemComm
发表日期: 2011
卷: 2, 期:4, 页:315-320
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 哈佛大学
英文摘要: A novel series of diphenylbutylpiperidine derivatives in which a benzo-five or six membered heterocycle was linked at the 4-position of the piperidine moiety were designed and synthesized. Structure-activity relationship (SAR) studies of these compounds indicated that some molecules show promising autophagy inducing activity. Replacement of the fluorine atom by a CF(3) group on the diphenyl part resulted in significant enhancement of the autophagy inducing effect. In the addition, a group of diphenylpentyl nitriles also showed similar bioactivities.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000290697800012
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/11088
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Chen G,Xia HG,Cai Y,et al. Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies[J]. MedChemComm,2011,2(4):315-320.
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