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学科主题: 生命有机化学
题名: Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers
其他题名: 细胞自吞噬诱导剂二苯基丁基哌啶的合成及构效关系研究
作者: Chen G(陈刚) ; Xia HG(夏宏光) ; Cai Y(蔡俞) ; Ma DW(马大为) ; Yuan JY(袁钧瑛) ; Yuan CY(袁承业)
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2011
卷: 21, 期:1, 页:234-239
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 哈佛大学医学院
英文摘要: A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and gamma-butyrolactone was also reported here. (C) 2010 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000285544400045
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/11086
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Chen G,Xia HG,Cai Y,et al. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers[J]. Bioorg. Med. Chem. Lett.,2011,21(1):234-239.
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