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学科主题: 生命有机化学
题名: Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7
其他题名: NECROSTATIN-7, 一种新型细胞坏死抑制剂的结构活性研究
作者: Zheng WH(郑卫红) ; Yuan CY(袁承业)
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2008
卷: 18, 期:18, 页:4932-4935
收录类别: SCI
部门归属: 上海有机所; Harvard Univ
英文摘要: Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modi. cations and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis. (C) 2008 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000259149400002
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/11068
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zheng WH,Yuan CY. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7[J]. Bioorg. Med. Chem. Lett.,2008,18(18):4932-4935.
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